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KMID : 0363120080210010027
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Korean Journal of Pain
2008 Volume.21 No. 1 p.27 ~ p.32
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The Role of Adrenergic and Cholinergic Receptors on the Antinociception of Korean Red Ginseng in the Spinal Cord of Rats
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Kim Se-Yol
Yoon Myung-Ha
Lee Hyung-Gon
Kim Woong-Mo
Lee Jae-Dam
Kim Yeo-Ok
Hwang Ran-Hee
Cui Jin-Hua
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Abstract
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Background: Experimental evidence indicates that ginseng modulate the nociceptive transmission. Authors
examined the role of adrenergic and cholinergic receptors on the antinociceptive action of Korean red ginseng
against the formalin-induced pain at the spinal level.
Methods: Catheters were inserted into the intrathecal space of male Sprague-Dawley rats. Fiftyμl of 5%
formalin solution was injected to the hindpaw for induction of pain and formalin-induced pain (flinching response)
was observed. The role of spinal adrenergic and cholinergic receptors on the effect of Korean red ginseng was
assessed by antagonists (prazosin, yohimbine, atropine and mecamylamine).
Results: Intrathecal Korean red ginseng produced a dose-dependent suppression of the flinching response
in the rat formalin test. All of prazosin, yohimbine, atropine and mecamylamine antagonized the antinociception
of Korean red ginseng.
Conclusions: Spinal Korean red ginseng is effective against acute pain and facilitated pain state evoked
by formalin injection. All of alpha 1, alpha 2, muscarinic and nicotinic receptors may play an important role
in the antinociceptive action of Korean red ginseng at the spinal level. (Korean J Pain 2008; 21: 27?32)
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KEYWORD
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adrenergic and cholinergic receptors, antinociception, formalin test, Korean red ginseng, spinal
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